解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Influenza A viruses infect a range of host species, including various mammals and more than 100 species of birds. For avian influenza viruses (AIV), prevalence varies between different groups of birds, with waterfowl showing the highest prevalence. We have sequenced the complete genome of A/Thick-billed Murre/Newfound...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-010-0504-5
更新日期:2010-10-01 00:00:00
abstract::Chinese equine infectious anemia virus (EIAV) attenuated vaccine is the first lentiviral vaccine with a successful application. In order to understand the correlation of viral genomic mutations with viral attenuation and with induced immunoprotective properties, we analyzed the proviral genome sequences of the EIAV-at...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-010-0491-6
更新日期:2010-08-01 00:00:00
abstract::Recent studies have shown that dual mutations in fp25K and p35 of Autographa californica nucleopolyhedrovirus (AcMNPV) result in a typical apoptotic infection on Trichoplusia ni cells, suggesting the involvement of FP25K on NPV-induced apoptosis. To examine the effect of fp25K deletion on Bombyx mori NPV (BmNPV)-induc...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-010-0492-5
更新日期:2010-08-01 00:00:00
abstract::Based on the genetic analysis, novel, naturally occurring recombinant norovirus strains were identified in Japan. Breakpoint analysis of recombinant norovirus showed that the recombination site was at the open reading frame ORF1/ORF2 overlap. ...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-010-0459-6
更新日期:2010-06-01 00:00:00
abstract::The reasons for adefovir dipivoxil (ADV) treatment failures appear diverse. Few studies have reported full-length hepatitis B virus (HBV) genome in patients with ADV treatment failures. The patients were from a phase III clinical trial that investigated the antiviral response to ADV in China. Seven patients had increa...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-009-0429-z
更新日期:2010-04-01 00:00:00
abstract::The intraspecies variability of capsid proteins of five viruses of the genus Comovirus was established. Inclusion of both capsid proteins to the sequence analysis reduces some uncertainties about species/strains demarcation criteria in the Comovirus genus. New approach is proposed for discrimination of Turnip ringspot...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-009-0443-1
更新日期:2010-04-01 00:00:00
abstract::Several tumor viruses, such as human T-cell leukemia virus (HTLV), human papilloma virus (HPV), human adenovirus, have high-oncogenic and low-oncogenic subtypes, and such subtype-specific oncogenesis is associated with the PDZ-domain binding motif (PBM) in their transforming proteins. HTLV-1, the causative agent of ad...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-009-0447-x
更新日期:2010-04-01 00:00:00
abstract:UNLABELLED:This study determined the complete nucleotide sequence of Beet cryptic virus 1 (BCV1). As expected by analogy to previously sequenced alphacryptoviruses, dsRNA1 (2008 bp) encodes a 72.5-kDa protein containing sequence motifs characteristic for RNA-dependent RNA polymerases (RdRp). In addition to the full-len...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-009-0432-4
更新日期:2010-04-01 00:00:00
abstract::A 13 amino acid residue insertion was found in the N-terminal region of the coat protein of several Maize dwarf mosaic virus isolates (MDMV). These insertions seem to be the result of a direct duplication event, but differ in some positions. In order to evaluate the influence of the insertion on the RNA secondary stru...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-009-0425-3
更新日期:2010-02-01 00:00:00
abstract::Dengue virus (DENV; Genus Flavivirus, Family Flaviviridae) has been circulating in Brazil since at least the mid-1980s and continues to be responsible for sporadic cases of Dengue fever and Dengue hemorrhagic fever throughout this country. Here, we describe the full genomes of two new Brazilian DENV-serotype 1 (DENV-1...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-009-0428-0
更新日期:2010-02-01 00:00:00
abstract::The complete genomic sequences of 13 PCV2 viruses obtained between 2005 and 2007 were analyzed in order to determine their phylogenetic relationship and identify possible recombination events between PCV2a and PCV2b. Twelve PCV2b viruses and one PCV2a virus were identified by phylogenetic analysis. Notably, two PCV2b ...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-009-0395-5
更新日期:2009-12-01 00:00:00
abstract::A unique feature of ascovirus infection is cleavage of host cells into virus containing vesicles. It has been suggested that the virus induces apoptosis, either by expression of a caspase or other means, which is then diverted toward vesicle formation. There is little known about the mechanism of vesicle formation. Re...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-009-0407-5
更新日期:2009-12-01 00:00:00
abstract::Partial genome segments of a begomovirus were previously amplified from Wissadula amplissima exhibiting yellow-mosaic and leaf-curl symptoms in the parish of St. Thomas, Jamaica and this isolate assigned to a tentative begomovirus species, Wissadula golden mosaic St. Thomas virus. To clone the complete genome of this ...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-009-0401-y
更新日期:2009-12-01 00:00:00
abstract::Wild-type measles virus (wtMeV) adapted well to cotton rat lung (CRL) cells after serial passages. In order to evaluate the contributions of the individual genes of wtMeV for adaptation, whole genome sequences of the adapted and original viruses were determined and analyzed. The results showed that there were two muta...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-009-0408-4
更新日期:2009-12-01 00:00:00
abstract::We previously identified a large homologous region (hr), hycu-hr6, in the genome of the Hyphantria cunea nucleopolyhedrovirus (HycuNPV) and suggested that hycu-hr6 was the largest baculovirus promoter enhancer hr identified so far. In this study, we examined the enhancement activity of hycu-hr6 against two promoters f...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-009-0406-6
更新日期:2009-12-01 00:00:00
abstract::H1 influenza A viruses that were distinct from the classical swine H1 lineage were identified in pigs in Canada in 2003–2004; antigenic and genetic characterization identified the hemagglutinin (HA) as human H1 lineage. The viruses identified in Canadian pigs were human lineage in entirety or double (human–swine) reas...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-009-0386-6
更新日期:2009-10-01 00:00:00
abstract::A filamentous virus was isolated in Angelica sinensis (Angelica sinensis (Oliv.) Diels) which shows mosaic symptoms on leaves in Minxian, Gansu province, China. According to morphology and molecular biology properties, this virus, which has a flexuous rod-shaped particle about 750 nm in length and 12 nm in width, was ...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-009-0361-2
更新日期:2009-08-01 00:00:00
abstract::Torque teno viruses (TTVs) are classified into the Anellovirus genus of the Circoviridae family. In addition to TTV isolates, TTV genogroup 3 also includes the 8 virus strains known as SENV-A to H. In this study, the prevalence of TTV group 3 viruses and that of SENV-D and H in particular were determined among the sta...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-009-0369-7
更新日期:2009-08-01 00:00:00
abstract::Yellow oat-grass plants (Trisetum flavescens L.) with mild mosaic and pronounced dwarfing symptoms were observed at different locations in the Czech Republic. Electron microscope observations of symptomatic plants revealed the presence of filamentous particles and inclusion bodies characteristic of the family Potyviri...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-009-0373-y
更新日期:2009-08-01 00:00:00
abstract::India is endemic for foot-and-mouth disease (FMD) and in recent years a unique group within serotype A, carrying a codon deletion at an antigenically critical site in capsid protein VP3 has emerged (VP3(59)-deletion group). This tempted us to analyze the noncoding region, which is an under represented area, though cri...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-009-0366-x
更新日期:2009-08-01 00:00:00
abstract::Mal de Río Cuarto virus (MRCV) is a newly described species of the genus Fijivirus, family Reoviridae. Compared with other plant-infecting genus of the family, the function and localization of MRCV and other Fijivirus proteins are poorly understood. Through analysis of viral particle purifications, we positively ident...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-009-0345-2
更新日期:2009-06-01 00:00:00
abstract::In our transient expression assays, the IE180 and TK promoters were markedly suppressed by the EP0 of the pseudorabies virus strains Ea and Fa (EP0/Ea, EP0/Fa). This is in contrast with the transactivating activity of EP0 from strain YS-81 (EP0/YS-81) in previous studies. Amino acid sequence alignment revealed several...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-008-0320-3
更新日期:2009-04-01 00:00:00
abstract::Chicken anemia virus (CAV) is the pathogen of chicken infectious anemia. To clarify the driving force in CAV evolution, we have detected positive selection in the structural protein gene VP1 by using maximum-likelihood models. Strong evidence was found that VP1 proteins were subject to the high rates of positive selec...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-008-0316-z
更新日期:2009-04-01 00:00:00
abstract::Nitric oxide (NO) has been shown to suppress Japanese encephalitis virus (JEV) RNA synthesis, viral protein accumulation, and virus release from infected cells. In this article, the potential viral structural proteins as the activators of NO product were studied at the molecular level. First, the genomic region encodi...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-008-0299-9
更新日期:2009-02-01 00:00:00
abstract::The Agrotis ipsilon multiple nucleopolyhedrovirus (AgipMNPV) is a group II nucleopolyhedrovirus (NPV) from the black cutworm, A. ipsilon, with potential as a biopesticide to control infestations of cutworm larvae. The genome of the Illinois strain of AgipMNPV was completely sequenced. The AgipMNPV genome was 155,122 n...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-008-0297-y
更新日期:2009-02-01 00:00:00
abstract::The broad distribution and prevalence of H3 subtype influenza viruses in avian and mammalian hosts constitutes a global threat to both human and veterinary health. In this present study, six H3N8 influenza viruses isolated from domestic ducks during 2004-2005 in northern China were genetically and phylogenetically cha...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-008-0300-7
更新日期:2009-02-01 00:00:00
abstract::Watermelon mosaic virus (WMV) is one of the most important viruses that causes different symptoms in Cucurbitaceae. WMV is a potyvirus with a worldwide distribution, but occurs most commonly in temperate and Mediterranean regions. Cucurbit species grown in Yazd, Esfahan, West Azerbaijan, Hormozgan, and Kerman province...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-008-0271-8
更新日期:2008-12-01 00:00:00
abstract::Three double-stranded RNA (dsRNA) segments from Aspergillus ochraceus isolate FA 0611, designated as AoR1, AoR2, and AoR3, were cloned and sequenced. AoR1 was identical with AoV dsRNA 1 previously reported from A. ochraceus ATCC 28706, which putatively encoded an RNA-dependent RNA polymerase of an unidentified mycovir...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-008-0265-6
更新日期:2008-12-01 00:00:00
abstract::Human T-cell leukemia virus type 1 (HTLV-1) is a causative agent of adult T-cell leukemia. HTLV-1 Tax1 transforming protein interacts with several PDZ domain-containing proteins, and the interaction is associated with the transforming activities of Tax1 as well as persistent HTLV-1 infection. In this study, we show th...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-008-0259-4
更新日期:2008-10-01 00:00:00
abstract::There are eight genotypes A-H of hepatitis B virus (HBV). Most genotypes are further divided into subgenotypes. Genotypes and subgenotypes influence the natural course of infection and therapy. We analysed nine sera from HBV carriers from Peru. Using the small hepatitis B surface protein HBs, all samples could be grou...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-008-0261-x
更新日期:2008-10-01 00:00:00
abstract::Rabies is an important public health problem in South East Asia, with cases in this part of the world contributing to about 70% of the global burden. A large number of rabies cases occur in India, however, there is no organized system of surveillance and hence there is a lack of reliable data. Moreover, comprehensive ...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-008-0223-3
更新日期:2008-06-01 00:00:00
abstract::The Tahyna virus (TAHV) is an important human pathogen in the Bunyaviridae family. To date, only the S and M segments of this virus have been sequenced, but the sequence of the L segment hasn't been established yet. In this study, we sequenced 963 nucleotides of the L segment of TAHV, comprising pre-motif A and motif ...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-008-0212-6
更新日期:2008-06-01 00:00:00
abstract::Although it is known that Cambodia is one of the high endemic area of hepatitis B virus (HBV) infection, molecular characterization of HBV circulating in this country has not been reported. In this study, pre-S gene of HBV from 12 Cambodian patients was sequenced. Phylogenetic analysis based on the pre-S gene sequence...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-008-0205-5
更新日期:2008-04-01 00:00:00
abstract::Foot-and-mouth disease (FMD) is the most contagious and devastating disease of livestock. Our previous studies demonstrated that TK(-)/gG(-)/P1(+), a recombinant expressing the FMDV capsid precursor protein (P1) based on attenuated pseudorabies virus (PRV) TK(-)/gG(-), could be used as a recombinant vaccine to protect...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-008-0204-6
更新日期:2008-04-01 00:00:00
abstract::Marek's disease (MD), a lymphoproliferative disease of chicken is caused by a highly cell-associated alpha-herpesvirus, Marek's disease virus (MDV). MDV replicates in chicken lymphocytes and establishes a latent infection within CD4(+) T cells. The expression analysis of limited viral transcripts have revealed differe...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-008-0203-7
更新日期:2008-04-01 00:00:00
abstract::Coxsackieviruses are important human pathogens that induce myocarditis and pancreatitis. However, there are no vaccines or therapeutic reagents for their clinical treatment. Although RNA interference (RNAi)-based approaches to the prevention of viral production have been developed recently, limitations to the in vivo ...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-007-0192-y
更新日期:2008-02-01 00:00:00
abstract::The biological diversity within viruses is one of the largest found in all other forms of nature. Many mechanisms contribute to virus diversity and include incorporating genetic material from the host, recombination between viruses belonging to the same or to a different family, and even recombination between viruses ...
journal_title:Virus genes
pub_type: 杂志文章,评审
doi:10.1007/s11262-007-0165-1
更新日期:2008-02-01 00:00:00
abstract::The complete nucleotide sequence of a virus isolated from soybean (Glycine max (L.) Merr.) in China, previously identified as a new strain of Tobacco necrosis virus A (TNV-A) based on its biological, serological properties, and coat protein (CP) sequence and named as TNV-A C, was determined and compared with that of T...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-007-0185-x
更新日期:2008-02-01 00:00:00
abstract::The complete genomic sequence of an isolate of Tobacco vein banding mosaic virus (TVBMV-YND) from Yunnan, China was determined by sequencing overlapping cDNA fragments obtained by RT-PCR with degenerate and/or specific primers. The genome is composed of 9,570 nucleotides (nt) excluding the 3'-terminal poly (A) tail an...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-007-0135-7
更新日期:2007-12-01 00:00:00
abstract::The complete genome sequence of Nootka lupine vein-clearing virus (NLVCV) was determined to be 4,172 nucleotides in length containing four open reading frames (ORFs) with a similar genetic organization of virus species in the genus Carmovirus, family Tombusviridae. The order and gene product size, starting from the 5'...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-007-0139-3
更新日期:2007-12-01 00:00:00